منابع مشابه
9.2.4 Sports E59 Perkins
A stumbling point for many learning to fly fish is being able to fly cast well enough to ‘present’ a fly to a feeding fish. Even among more skilled fly fishers, learning to fly cast better is often a bottleneck towards advancement in the sport. Fly casting instruction today relies on the visual inspection of the fly casting stroke and the resulting ‘loop’ of fly line. These qualitative visual c...
متن کاملHelicobacter pylori CagL Y58/E59 Mutation Turns-Off Type IV Secretion-Dependent Delivery of CagA into Host Cells
The type IV secretion system (T4SS) is a major virulence determinant of the gastric pathogen Helicobacter pylori. The CagL protein is a specialized adhesin of the corresponding T4SS pilus, which establishes initial contact with the integrin β1 receptor on host target cells. Recent studies proposed that Y58 and E59 amino acid polymorphisms in CagL increase the virulence of H. pylori strains by e...
متن کاملComment on: Khurana et al. The Diagnosis of Neonatal Diabetes in a Mother at 25 Years of Age. Diabetes Care 2012;35:e59
We read with interest the observation by Khurana et al. (1) regarding the speculative treatment of their case of neonatal diabetes (ND) pending molecular genetic confirmation. The authors report the successful trial of a sulfonylurea in a baby diagnosed with diabetes on day 2 of life in whom an activating KCNJ11mutation was subsequently identified. Khurana et al. suggest a controlled trial of s...
متن کاملCorrection: Correction: H. pylori CagL-Y58/E59 Prime Higher Integrin α5β1 in Adverse pH Condition to Enhance Hypochlorhydria Vicious Cycle for Gastric Carcinogenesis
BACKGROUND/AIMS H. pylori CagL amino acid polymorphisms such as Y58/E59 can increase integrin α5β1 expression and gastric cancer risk. Hypochlorhydria during chronic H. pylori infection promotes gastric carcinogenesis. The study test whether CagL-Y58/E59 isolates may regulate integrin α5β1 to translocate CagA via the type IV secretory system even under adverse pH conditions, and whether the int...
متن کاملCorrection: H. pylori CagL-Y58/E59 Prime Higher Integrin α5β1 in Adverse pH Condition to Enhance Hypochlorhydria Vicious Cycle for Gastric Carcinogenesis
The authors have provided DNA sequencing and RT-PCR data in supporting information files: Figure S1 shows a diagram of the construction of the cagL mutant (A), revertant, and amino acid replacement mutants (B). Figure S2 confirms the cagL mutant, revertant, and amino acid replacement mutants using PCR. Figure S3 shows sequencing results of H. pylori clinical strain Hp1033 wild type, cagL insert...
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ژورنال
عنوان ژورنال: Arthropod Management Tests
سال: 2012
ISSN: 2155-9856
DOI: 10.4182/amt.2012.e59